The Miraculous Results Of Extremely High Doses Of The Sunshine Hormone Vitamin D3 My Experiment With Huge Doses Of D3 From 25,000 To 50,000 To 100,000 Iu A Day Over A 1 Year Period

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Biologists in general tend to also discuss the evolutionary puzzle of homosexuality as mainly a human condition. Applying it to just humans makes the fact conveniently unique and a special category that can be ignored. They do it all the time. Menopause and suicide are also promoted by most biologists as being exceptions that apply to just humans. NEW PUBMED search tool….. search all 48 Horvath aging genes against your topic of interest (For example- WRN or telomere) and see which genes pop up…..at the end of this post…let me know if you find anything exciting!

Human chorionic gonadotropin (hCG) may be a marker of systemic oxidative stress in normote It turns out, I believe, given the connection between development and aging we now understand thanks to Horvath, that the normal Werner’s syndrome protein apparently is also the coordinator and master regulator of all other development genes and transcription factors. The WRN protein does not do all the work itself, it has apparently coopted downstream transcription/differentiation factors and tells them when to be turned on and turned off. WRN is the master regulator of development.At this point in evolution, reproduction likely occurred through parthenogenesis and possibly the complete dissociation of the multi-celled organism into a myriad of single cell, clonal spores; in an unrestricted environment, this would provide a great reproductive advantage.” We observed previously that after long-term suppression of luteinizing hormone (LH) and thus of Leydig cell steroidogenesis, restimulation of the Leydig cells by LH resulted in significantly higher testosterone production than by age-matched cells from control rats. These studies suggest that stimulation over time may elicit harmful effects on the steroidogenic machinery, perhaps through alteration of the intracellular oxidant-to-antioxidant balance. Herein we compared the effects of LH stimulation on stress response genes, formation of intracellular reactive oxygen species (ROS), and ROS-induced damage to ROS-susceptible macromolecules (DNA) in young and in aged cells. Microarray analysis indicated that LH stimulation resulted in significant increases in expression of genes associated with stress response and antiapoptotic pathways. Short-term LH treatment of primary Leydig cells isolated from young rats resulted in transiently increased ROS levels compared to controls. Aged Leydig cells also showed increased ROS soon after LH stimulation. However, in contrast to the young cells, ROS production peaked later and the time to recovery was increased. In both young and aged cells, treatment with LH resulted in increased levels of DNA damage but significantly more so in the aged cells. DNA damage levels in response to LH and the levels of intracellular ROS were highly correlated. Taken together, these results indicate that LH stimulation causes increased ROS production by young and aged Leydig cells and that while DNA damage occurs in cells of both ages, there is greater damage in the aged cells. This updated edition has a fascinating new look at diabetes as an evolved defense to freezing damage in winter gone out of control So my examination of the 200+ journal articles in Pub Med that contain the term “Yamanaka factors ” yields some very interesting results… It turns out that it appears that the general rule is that adding antioxidants to the Yamanaka factors greatly increases their differentiation into specific cell lines (presumably through increasing general cytosine methylation and shutting down of various genes.). It also appears to be generally true that adding free radicals to the mix greatly increases the loss of differentiation of the cells and allows them to become pluripotent (blank) stem cells (presumably by increasing loss of cytosine methylation) . Hormone Changes >>>> Gain of Methylation >>> Suppression of genes required for cellular differentiation.

In summary, we have found that WRN protein, besides its role in DNA repair, functions to safeguard heterochromatin stability ( fig. S11). Our results unveil that the progressive heterochromatin disorganization observed in WRN deficient MSCs underlies cellular aging, but more extensive studies are needed to examine its role during physiological aging.”Recent note-which we will later find this to be not group but an even higher-level form of selection called species selection which I have refined and coined the name “Predator Selection”). A painful snapping hip syndrome which I had been suffering from for 23 years and no Dr could help me-It is now 100% gone. No pain and NO SNAPPING!!

After about 4 months upped the dose to 50,000 IU a day or 150X the old recommended “safe” dose I then boosted it to 100,000 IU a day or 300 x TIMES the old maximum safe dose! LARP1 binds to and regulates the translation of terminal oligopyrimidine motif (TOP mRNAs ) and can directly interact with the 5′ cap of mRNAs. [17] [18] It has also been shown to interact with the 3′ end and coding regions (CDS) of other genes. [17] LARP1 protein colocalizes with stress granules and P-bodies , [19] which function in RNA storage and degradation . It has been suggested that LARP1 functions in P-bodies to attenuate the abundance of conserved Ras– MAPK mRNAs. The cluster of LARP1 homologs may function to control the expression of key developmental regulators. [19]So of course this study raises the important question-What is the purpose of the evolution of programmed aging and how could it evolve? Please Notice I did not cross out the hormonal/neuroendocrine theory of aging…that one is still valid and will be found to be the upstream controller of the programmed loss of cellular differentiation primarily through the large/dramatic post age 50 increases in LH, FSH, and hCG with the simultaneous dramatic decline in night time melatonin peaks, dhea, pregnenolone, and progesterone. And it turns out that there are still animals on earth that can reproduce this way..take the immortal jellyfish for example: I think it is the most important study concerning aging and always will be. And I have been studying aging for 35+ years and have seen almost everything! Horvath’s travels through the methylation of the DNA of so many animals is certainly as important as and probably more so than Darwin’s 5 years on the HMS Beagle. Oncogenic transcription factors are known to mediate the conversion of somatic cells to tumour or induced pluripotent stem cells (iPSCs).