Lehninger Principles of Biochemistry + website

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Insights on top learning objectives and assignments to review are surfaced just-in-time (7 day period) Interactive Metabolic Map and Animated Mechanism Videos, problem-solving videos, and case studies are integrated into Lecture Slides and available as stand-alone resources Instructor Activity Guides, developed with instructors and tied to the principles framework, include both instructor material and assessable student material A design guided by learning science research. Co-designed through extensive collaboration and testing by both students and faculty including two levels of Institutional Review Board approval for every study of Achieve Clear principles are identified at the outset of each chapter and called out with icons in the narrative of the chapter. The end-of-section summaries parallel the section content. Hundreds of new or revised figures make current research accessible to the biochemistry student. Contents

Tools for understanding are provided including ‘Key Conventions’ and ‘Special Themes’ (Metabolic Integration, Obesity, and Diabetes, Evolution) as well as ‘Medical Insights and Applications-Icons’ used throughout the book denote material of special medical interest and updated to reflect the most current content. Expanded coverage and updating of the biochemical connections between obesity, metabolic syndrome, and type 2 diabetes

Where possible, figures have been simplified, and many figures now have step-by-step annotations, reducing caption length. New information on the initiation of replication and the dynamics at the replication fork, introducing AAA+ ATPases and their functions in replication and other aspects of DNA metabolism Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry

Available for the first time in Achieve, the definitive reference text for biochemistry Lehninger Principles of Biochemistry, 8e helps students focus on the most important aspects of biochemistry-- the principles! Dave Nelson, Michael Cox, and new co-author Aaron Hoskins identify the most important principles of biochemistry and direct student attention to these with icons and resources targeted to each principle.Animated Techniques’ include short animations of laboratory techniques. Designed to provide students with an overview of protocol, these animations give students a conceptual understanding of what is happening at the chemical level. Chemical Logic Figures highlight the conversation of mechanisms and illustrate patterns that make learning pathways easier. (Provided for each of the central metabolic pathways) New Medical section on G protein coupled receptors (GCPRs) discusses the range of diseases for which drugs target GPCRs

Lehninger Principles of Biochemistry, 8e continues to help students navigate the complex discipline of biochemistry with a clear and coherent presentation. Renowned authors David Nelson, Michael Cox, and new co-author Aaron Hoskins have focused this eighth edition around the fundamental principles to help students understand and navigate the most important aspects of biochemistry. Text features and digital resources in the new Achieve platform emphasize this focus on the principles, while coverage of recent discoveries and the most up-to-date research provide fascinating context for learning the dynamic discipline of biochemistry. In-text Worked Examples take students through particular difficult equations to improve their quantitative problem-solving skills.Animated Mechanisms’ have been designed to enhance lecture or student study and help with visualization. Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase A, adenylyl cyclase, and phosphodiesterase, and localized puffs and waves of Ca2+

Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing! Migration Tool to move your assignments from your previous Sapling Course into your new Achieve course

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New box on G proteins, proteins that regulate their GTPase activity, and the medical consequences of defective G protein function Chemical Logic discusses the common biochemical reaction types that underlie all metabolic reactions, helping students to connect organic chemistry with biochemistry. New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes The summary of principals and the highlighting of these principals throughout the text. This is really helpful! The Boxes with additional information, particularly clinical relevance of the material. Most of my students are pre-med and it helps them engage in the material better if there is clinical relevance. The problems at the end of the chapter. These are really beneficial for the students who want to make sure they understand the material." --Robin Haynes, Harvard University New medical box on the use of topoisomerase inhibitors in the treatment of bacterial infections and cancer, includes material on ciprofloxacin (the antibiotic effective for anthrax)